Record Display for the EPA National Library Catalog


Main Title Examination of Immune Parameters and Host Resistance Mechanisms in B6C3F1 Mice Following Adult Exposure to 2,3,7,8-Tetrachlorodibenzo-'p'-Dioxin.
Author House, R. V. ; Lauer, L. D. ; Murray, M. J. ; Thomas, P. T. ; Ehrlich, J. P. ;
CORP Author Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. ;IIT Research Inst., Chicago, IL. Life Sciences Research Div.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher c1990
Year Published 1990
Report Number EPA-68-02-4450; EPA/600/J-90/351;
Stock Number PB91-163659
Additional Subjects Immune system ; Tetrachlorodibenzodioxins ; Toxicology ; Antibody formation ; Mice ; IgM ; IgG ; Dose-response relationships ; Macrophage ; Disease susceptibility ; Viral antigens ; Virus diseases ; Listeria monocytogenes ; Reprints ; Viral hemagglutinins
Library Call Number Additional Info Location Last
NTIS  PB91-163659 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Adult female B6C3F1 mice were given a single IP dose of 0, 0.1, 1.0, or 10.0 micrograms/kg TCDD and examined for immune function and host resistance seven to ten days later. Exposure to TCDD resulted in a significant dose-related decrease in induction of both IgM and IgG antibody-forming cells. The suppression was noted for both T-dependent and T-independent antigens. TCDD at a dosage of 10 micrograms/kg was shown to suppress production of viral hemagglutinin. In contrast, TCDD exposure had no significant effect on natural killer cell function, production of interferon, or various parameters of macrophage function. Host resistance assessment revealed a significant increase in susceptibility to fatal infection with influenza virus, but no significant alteration in susceptibility to infection with the bacterium Listeria monocytogenes. (Copyright (c) 1990 by Hemisphere Publishing Corporation.)