| Main Title |
Symposium Overview: Advances in Biologically Based Models for Respiratory Tract Uptake of Inhaled Volatiles. |
| Author |
Medinsky, M. A. ;
Kimbell, J. S. ;
Morris, J. B. ;
Gerde, P. ;
Overton, J. H. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. ;Connecticut Univ., Storrs. Dept. of Renewable Natural Resources. ;National Inst. of Occupational Health, Solna (Sweden). |
| Publisher |
c1993 |
| Year Published |
1993 |
| Report Number |
EPA/600/J-93/335; |
| Stock Number |
PB93-229532 |
| Additional Subjects |
Dose-response relationships ;
Respiratory tract ;
Pharmacokinetics ;
Respiratory airflow ;
Biochemistry ;
Metabolism ;
Absorption ;
Risk assessment ;
Toxicity ;
Models ;
Reprints ;
Volatile organic compounds
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-229532 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Physiologically based pharmacokinetic models for volatile organic chemicals typically describe the respiratory tract as a single compartment in which chemicals in the alveolar air space and the arterial blood are in instantaneous equilibrium. A functional role for the upper respiratory tract in the uptake of volatile chemicals has been largely ignored. Airflow patterns in the respiratory tract, regional metabolism, diffusion-dependent uptake, and the cyclic nature of respiration are now being incorporated into current models. Use of dosimetric models that incorporate relevant biology for inhaled chemicals will ultimately result in more meaningful human risk assessments. (Copyright (c) 1993 Society of Toxicology.) |
