Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Influence of Phosgene Inhalation on Extrapulmonary Effects in Mice (Journal Version).
Author Illing, J. W. ; Mole, M. L. ; Graham, J. A. ; Williams, T. B. ; Menache, M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/252;
Stock Number PB89-144984
Additional Subjects Phosgene ; Toxicity ; Hazardous materials ; Sleep disorders ; Acid halides ; Phenobarbital ; Exposure ; Mice ; Laboratory animals ; Liver ; Gases ; Poisons ; Military chemical agents ; Reprints ; Toxic substances ; Air pollution effects(Animals) ; Inhalation ; Occupational safety and health ; Cytochrome P-450
Library Call Number Additional Info Location Last
NTIS  PB89-144984 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/08/1989
Collation 10p
Results were: exposure of mice for 4 hours to phosgene concentrations ranging from 0.1 ppm to 0.5 ppm resulted in a significant increase in pentobarbital-induced sleeping time vs. air-exposed animals. Blood pentobarbital levels were measured following a 4 hr exposure to 0.5 ppm phosgene. Although there were no significant differences in the slopes of the clearance curves for phosgene- and air-exposed animals, the half life of pentobarbital was increased by 35%. In separate studies, cytochrome P-450, body weights and liver weights were determined for mice exposed to 0.5 ppm phosgene or to filtered air for 4 hrs. No differences were observed for any of the measurements. These results suggest that phosgene has extrapulmonary effects without causing direct effects on the cytochrome P-450 levels. (Copyright (c) 1988 Hemisphere Publishing Corp.)