| Main Title |
Influence of Ozone on Pentobarbital Pharmacokinetics in Mice. |
| Author |
Graham, J. A. ;
Menzel, D. B. ;
Mole, M. L. ;
Miller, F. J. ;
Gardner, D. E. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Duke Univ., Durham, NC. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/451; |
| Stock Number |
PB87-116430 |
| Additional Subjects |
Toxicology ;
Drugs ;
Ozone ;
Mice ;
Laboratory animals ;
Reprints ;
Pentobarbital ;
Pharmocokinetics
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB87-116430 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
It had been shown that 3 to 5 hr exposures to ambient concentrations of ozone (O3) increase pentobarbital-induced sleeping time in female mice, hamsters, and rats without decreasing heptatic cytochrome P-450 levels or selected mixed function oxidases. To elucidate potential mechanisms involved, clearance of pentobarbital from the blood of O3-exposed mice was examined. Pentobarbital clearance followed first-order kinetics with a one-compartment model. Mice exposed to 1960 micrograms per cu. m. (1ppm) for 5 hr had a 71% increase in the plasma half-life of pentobarbital. It therefore appears possible that pentobarbital-induced sleeping time is increased due to a decrease in hepatic metabolism of pentobarbital. |
