Record Display for the EPA National Library Catalog


Main Title Analysis of the Genotoxicity of Nine Acrylate/Methacrylate Compounds in L5178Y Mouse Lymphoma Cells.
Author Dearfield, K. L. ; Millis, C. S. ; Harrington-Brock, K. ; Doerr, C. L. ; Moore, M. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Durham, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/227;
Stock Number PB90-146036
Additional Subjects Toxicity ; Lymphomas ; Acrylates ; Methacrylates ; Tables(Data) ; Graph(Charts) ; Mice ; Mutations ; Cell nucleus ; Esters ; Reprints ; Mutagenicity tests ; Dose-response relationships ; Risk assessment ; Cultured cells
Library Call Number Additional Info Location Last
NTIS  PB90-146036 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Nine acrylate/methacrylate esters were tested for the induction of mutations, aberrations, and micronuclei in cultured L5178Y mouse lymphoma cells without exogenous activation. With the exception of 2-ethylhexyl acrylate, and dicyclopentenyloxyethyl methacrylate which produced equivocal responses, the other seven compounds (2-hydroxyethyl acrylate, dicyclopentenyloxyethyl acrylate, tetraethylene glycol diacrylate, tetraethylene glycol dimethacrylate, trimethylolpropane triacrylate, trimethylolpropane trimethacrylate, and pentaerythritol triacrylate) produced positive genotoxic responses with different potencies. Primarily small-colony, TFT-resistant mutants were induced, suggesting a clastogenic mechanism that was supported by increased aberration and micronucleus frequencies. Generally, it was found that multifunctional compounds (esters with more than 1 functional vinyl group) required lower concentrations than monofunctional compounds to induce maximal cytotoxic, mutagenic, and clastogenic responses. In addition, acrylates were generally more potent than their corresponding methacrylates.