Record Display for the EPA National Library Catalog


Main Title Influence of Ozone on Xenobiotic Metabolism.
Author Graham, Judith A. ; Menzel, Daniel B. ; Miller, Frederick J. ; Illing, Joseph W. ; Ward, Robert ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Duke Univ., NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/D-83-063;
Stock Number PB83-243238
Additional Subjects Ozone ; Toxicology ; Metabolism ; Mice ; Females ; Physiological effects ; Exposure ; Sensitivity ; Concentration(Composition) ; Sleep ; Drugs ; Paralysis ; Pentobarbital ; Inhibitors ; Enzymes ; Air pollution effects(Animals) ; Pharmacokinetics
Library Call Number Additional Info Location Last
NTIS  PB83-243238 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
Gardner et al. found that ozone (O3) exposure increased pentobarbital induced sleeping time in female CD-1 mice. The animals were exposed to 1960 micrograms O3/cu. m (1 ppm) for 3 hr/day for up to 7 days, but an effect was only observed on the second and third day of exposure. Since animals awake from PEN-induced S.T. because of hepatic xenobiotic metabolism, it was hypothesized that O3 exposure resulted in effects that occured in the liver, making investigations to elucidate the mechanisms involved of interest. To this end, a series of studies were performed which are summarized in the report.