||Influence of Ozone on Pentobarbital-induced Sleeping Time in Mice, Rats, and Hamsters.
Graham, Judith A. ;
Menzel, Daniel B. ;
Miller, Frederick J. ;
Illing, Joseph W. ;
Gardner, Donald E. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Hypnotics and sedatives ;
Laboratory animals ;
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Prior studies have shown that ozone (O3) increases pentobarbital (PEN)-induced sleeping time (S.T.) in female mice, rats, and hamsters. To investigate some potential mechanisms producing these effects, the authors measured zoxazolamine-induced paralysis time and thiopental- and hexobarbital-induced S.T., all of which were prolonged significantly in mice following a 5-hr exposure to 1960 micrograms O3/cu m (1 ppm).