The report gives preliminary data on methodology for candidate principal organic hazardous constituents (POHCs) that represent a variety of compound types, including alcohols, esters, chlorinated aliphatics and aromatics, carboxylic acids, aliphatic and aromatic amines, nitrated aromatics, nitrosamines, hydrazines, nitriles, organosulfur compounds, and polynuclear aromatics and heterocyclics. This work (and that under Contract 68-02-2685, Task 111) involved the evaluation of generalized GC/FID, GC/MS, and HPLC/UV methods for determining approximately 170 compounds from the approximately 400 compounds in Appendix VIII, Part 261, 40 CFR. However, the survey-analysis portion of waste characterization often targeets specific compounds for determnation in incinerator effluent that are not amenable to previously developed methods. Therefore, current research involves the development of specific GC/FID, GC/MS, and HPLC/UV methods for the determination of several of these compounds. The EPA has proposed regulations for owners and operators of facilities that treat hazardous wastes by incineration to ensure that these incinerators will be operated in an environmetally responsible manner. The primary criterion upon which the operational specifications are based is the destruction and removal efficiency (DRE) of the incinerator (= or >99.995).