| Main Title |
Norepinephrine Decreases EGF (Epidermal Growth Factor) Binding in Primary Rat Hepatocyte Cultures. |
| Author |
Cruise, J. L. ;
Cotecchia, S. ;
Michalopoulos, G. ;
|
| CORP Author |
Duke Univ. Medical Center, Durham, NC. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC.;National Institutes of Health, Bethesda, MD. |
| Year Published |
1986 |
| Report Number |
EPA-CR-811687; EPA/600/J-86/455; |
| Stock Number |
PB88-185566 |
| Additional Subjects |
Norepinephrine ;
Cells(Biology) ;
Rats ;
Laboratory animals ;
Reprints ;
Epidermal growth factor-Urogastrone ;
Receptors(Adrenergic) ;
DNA ;
Phosphoinositides
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-185566 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture. The effect was maximal after 1 hour of incubation with NE and could be blocked by the presence of an alpha 1 -specific adrenergic receptor antagonist. The inhibition of binding correlates with the ability of NE to enhance hepatocyte DNA synthesis in the presence of EGF and appears to be mediated by a reduction of EGF receptor number, without a significant change in receptor affinity. (Copyright (c) 1986 Alan R. Liss, Inc.) |
