Record Display for the EPA National Library Catalog


Main Title Hazard Assessment Using an Integrated Physiologically-Based Dosimetry Modeling Approach: Ozone.
Author Miller, F. J. ; Overton, J. H. ; Smolko, E. D. ; Menzel, D. B. ; Graham, R. C. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Duke Univ. Medical Center, Durham, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/D-87/040;
Stock Number PB87-147096
Additional Subjects Air pollution ; Ozone ; Mathematical models ; Respiratory diseases ; Hazards ; Risk ; Toxicology ; Environmental tests ; Dosimetry modelling approach ; Health effects ; Risk assessment ; Air pollution sampling
Library Call Number Additional Info Location Last
NTIS  PB87-147096 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 31p
A physiologically-based dosimetry modeling approach can provide a framework for integrating various components of hazard assessments to obtain interspecies dose-response curves as part of the risk assessment process. The methodology presented for developing dose-response curves is illustrated within the context of the inhalation toxicology of a ubiquitous air pollutant, ozone. Major components of the approach are discussed, including a data-based management system, the Critical Toxicity Reference System, and a physiological based dosimetry model for ozone absorption in the lower respiratory tract of mammals. Features and characteristics of the two components are discussed. When the ozone dosimetry modeling approach is sufficiently developed, it can provide improved estimates for dose-response relationships in experimental animals, leading to improved estimates of human health risks.