Record Display for the EPA National Library Catalog


Main Title Influence of Ozone on Pentobarbital Pharmacokinetics in Mice.
Author Graham, J. A. ; Menzel, D. B. ; Mole, M. L. ; Miller, F. J. ; Gardner, D. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Duke Univ., Durham, NC.
Year Published 1985
Report Number EPA/600/J-85/451;
Stock Number PB87-116430
Additional Subjects Toxicology ; Drugs ; Ozone ; Mice ; Laboratory animals ; Reprints ; Pentobarbital ; Pharmocokinetics
Library Call Number Additional Info Location Last
NTIS  PB87-116430 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
It had been shown that 3 to 5 hr exposures to ambient concentrations of ozone (O3) increase pentobarbital-induced sleeping time in female mice, hamsters, and rats without decreasing heptatic cytochrome P-450 levels or selected mixed function oxidases. To elucidate potential mechanisms involved, clearance of pentobarbital from the blood of O3-exposed mice was examined. Pentobarbital clearance followed first-order kinetics with a one-compartment model. Mice exposed to 1960 micrograms per cu. m. (1ppm) for 5 hr had a 71% increase in the plasma half-life of pentobarbital. It therefore appears possible that pentobarbital-induced sleeping time is increased due to a decrease in hepatic metabolism of pentobarbital.