Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Species and Strain Comparison of Acute Neurotoxic Effects of Trimethyltin in Mice and Rats.
Author Chang, L. W. ; Wenger, G. R. ; McMillan, D. E. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA/600/J-83-049;
Stock Number PB84-101260
Additional Subjects Toxicology ; Central nervous system ; Pathology ; Comparison ; Mice ; Rats ; Laboratory animals ; Dosage ; Reprints ; Tin/trimethyl ; Neurotoxicity
Library Call Number Additional Info Location Last
NTIS  PB84-101260 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 17p
Pathological changes in the central nervous system in two strains of mice (BALB/c and C57BL/6) and two strains of rats as a result of trimethyltin (TMT) intoxication were compared. Both strains of mice were administered with trimethyltin chloride at a dosage of 3.0 mg TMT-C1/kg b.w. while both strains of rats were exposed to 7.5mg TMT-C1/kg b.w. Animals were sacrified at the time of development of observable neurological signs (tremor, aggression): 2 days for both strains of mice, 3 days for Long Evans (LE) rats, and 5 days for Sprague Dawley (SD) rats. It was found that there were both species and strain differences in TMT toxicity.