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Main Title Possible Antiestrogenic Activity of Lindane in Female Rats (Journal Version).
Author Chadwick, R. W. ; Cooper, R. L. ; Chang, J. ; Rehnberg, G. L. ; McElroy, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/265;
Stock Number PB89-143697
Additional Subjects Chlorobenzenes ; Obesity ; Hormone antagonists ; Tables(Data) ; Rats ; Toxicity ; Food consumption ; Reproduction(Biology) ; Females ; Body weight ; Reprints ; Estrogen antagonists ; Lindane ; Reproductive disorders
Library Call Number Additional Info Location Last
NTIS  PB89-143697 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
During chronic treatment of weanling female rats with daily injections (0.069 mmol/kg of gamma-hexachlorocyclohexane (lindane, gamma-HCH), the treatment induced a significant 20% increase in body weight after 110 days. Further investigation with 0, 5, 10, 20 and 40 mg/kg lindane confirmed a significant increase in average body weight gain at the two highest doses after 10 weeks of treatment. Significantly greater food consumption was observed and the Lee Index indicated that lindane treatment induced obesity. In addition to obesity, lindane caused a delay in vaginal opening, disrupted estrous cycling, reduced pituitary and uterine weight and elevated food consumption during proestrus. These responses suggest that, by inducing alterations in the reproductive function of the female rate and by interfering with hormonal regulation of energy balance, lindane may be antiestrogenic rather than estrogenic as previously proposed. (Copyright (c) 1988 VCH Publishers, Inc.)