Record Display for the EPA National Library Catalog


Main Title Measurement of Epididymal Sperm Motility as a Test Variable in the Rat.
Author Linder, R. E. ; Strader, L. F. ; McElroy, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/021;
Stock Number PB86-187200
Additional Subjects Rats ; Laboratory animals ; Measurement ; Reprints ; Animal models ; Sperm motility ; Test variable
Library Call Number Additional Info Location Last
NTIS  PB86-187200 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Several environmental contaminants, notably dibromochloropropane (Whorton et al. 1977) and kepone (Taylor et al. 1978; Cannon et al, 1978) have been implicated in sperm deficiencies among occupationally exposed males. These incidents emphasize the need for adequate testing of chemicals for effects on the male reproductive system. Although important in clinical diagnosis, the evaluation of sperm motility has not been used extensively as a tool in chemical toxicology, particularly in commonly used small laboratory species. Measurements of sperm motility parameters are complicated by several variables including sample manipulation, temperature, cell concentration, time factors and the method of quantitation. In the present study, a simple objective procedure to estimate the proportion of motile epididymal spermatozoa in the rat has been developed.