Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Statistical approach to predicting chronic toxicity of chemicals to fishes from acute toxicity test data /
Author Mayer, Foster L. ; Krause, G. F. ; Ellersieck, M. R. ; Lee, G.
Other Authors
Author Title of a Work
Krause, Gary F.
Kilersieck, Mark R.
Lee, Gunhee.
CORP Author Environmental Research Lab., Gulf Breeze, FL. ;Missouri Agricultural Experiment Station, Columbia.
Publisher U.S. Environmental Protection Agency, Environmental Research Laboratory, Office of Research & Development,
Year Published 1992
Report Number EPA/600/R-92/091; EPA/SW/DK-92/047A
Stock Number PB92-169655
OCLC Number 45877986
Subjects Acute toxicity testing. ; Fishes--Effect of chemicals on.
Additional Subjects Water pollution effects ; Fishes ; Toxicity ; Chemical compounds ; Statistical analysis ; Documentation ; Exposure ; Concentration(Composition) ; Mortality ; Fishkill ; Growth stages ; Fish physiology ; Risk assessment ; Multifactor probit analysis
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-R-92-091 Headquarters Library/Washington,DC 02/06/2017
NTIS  PB92-169655 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation vi, 94 pages : illustrations ; 28 cm
A comprehensive approach to predicting chronic toxicity from acute toxicity data was developed in which simultaneous consideration is given to concentration, degree of response, and time course of effect. A consistent endpoint (lethality) and degree of response (0%) were used to compare acute and chronic tests. Predicted no-effect concentrations were highly accurate 92% of the time (within a factor of 2.0 of the limits of the maximum acceptable toxicant concentrations for lethality) and did not vary by more than a factor of 4.8 when the technique was applied to a data base of 18 chemicals and 7 fish species. Growth effects can be predicted from chronic lethality, but reproductive effects should not be.
Includes bibliographical references (page 61). Microfiche.