||Biochemical Events during Initiation of Rat Hepatocarcinogenesis.
Dragan, Y. P. ;
Hully, J. R. ;
Nakamura, J. ;
Mass, M. J. ;
Swenberg, J. A. ;
||Wisconsin Univ.-Madison. McArdle Lab. for Cancer Research. ;North Carolina Univ. at Chapel Hill. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch.;National Cancer Inst., Bethesda, MD.;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
||EPA-R-816214 ;NCI-CA-07175; EPA/600/J-94/546;
Tracer techniques ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Carcinogenesis is a multistep, multistage process that begins with irreversible, but heritable damage to a single cell. The partial hepatectomy/diethylnitrosamine (DEN) model of rat hepatocarcinogenesis has been well characterized and many aspects of the stage of initiation are known. In this manuscript male Fischer rats were subjected to a 70% partial hepatectomy and at the peak of cell proliferation 24 h later were adminsitered the solvent, trioctanoin, or 10 mg DEN/kg. The presence of 3 promutagenic adducts was seen during enhanced cellular proliferation and may contribute to the initiation that results in this model for hepatocarcinogenesis.