Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Human Carcinogenesis by Arsenic.
Author Mass, M. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/316;
Stock Number PB92-227578
Additional Subjects Carcinogenesis ; Arsenic ; Toxicity ; Cocarcinogenesis ; Neoplastic cell transformation ; Risk assessment ; Mutagenicity tests ; Syrian hamsters ; Human ; Foreign technology
Library Call Number Additional Info Location Last
NTIS  PB92-227578 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/01/1993
Collation 10p
Arsenic is one of the few human carcinogens for which there is not yet a reliable animal cancer model. As such, the classification of arsenic as a carcinogen is based upon data derived from human epidemiologic studies. Although the mechanisms of action of arsenic as a toxic agent have been known for many years, the inability to produce cancer in laboratory animals with arsenic has confounded the operational characterization of arsenic as initiator, promoter, complete carcinogen, or cocarcinogen for humans. Arsenic is clearly a genotoxic agent that induces chromosomal aberrations, micronuclei, and sister chromatid exchange in mammalian cells as well as neoplastically transforms Syrian hamster embryo cells; however, it is not a classical point mutagen. The manuscript reviews some of the scientifically based issues relating to arsenic and risk assessment. (Copyright (c) Science and Technology Letters 1991.)