| Main Title |
Biochemical Events during Initiation of Rat Hepatocarcinogenesis. |
| Author |
Dragan, Y. P. ;
Hully, J. R. ;
Nakamura, J. ;
Mass, M. J. ;
Swenberg, J. A. ;
|
| CORP Author |
Wisconsin Univ.-Madison. McArdle Lab. for Cancer Research. ;North Carolina Univ. at Chapel Hill. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch.;National Cancer Inst., Bethesda, MD.;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. |
| Publisher |
c1994 |
| Year Published |
1994 |
| Report Number |
EPA-R-816214 ;NCI-CA-07175; EPA/600/J-94/546; |
| Stock Number |
PB95-148086 |
| Additional Subjects |
Biochemistry ;
Carcinogenesis ;
Liver ;
Models ;
Rats ;
Cells(Biology) ;
Tracer techniques ;
Solvents ;
Enzymes ;
Neoplasms ;
Reprints ;
Trioctanoin
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB95-148086 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Carcinogenesis is a multistep, multistage process that begins with irreversible, but heritable damage to a single cell. The partial hepatectomy/diethylnitrosamine (DEN) model of rat hepatocarcinogenesis has been well characterized and many aspects of the stage of initiation are known. In this manuscript male Fischer rats were subjected to a 70% partial hepatectomy and at the peak of cell proliferation 24 h later were adminsitered the solvent, trioctanoin, or 10 mg DEN/kg. The presence of 3 promutagenic adducts was seen during enhanced cellular proliferation and may contribute to the initiation that results in this model for hepatocarcinogenesis. |
