Record Display for the EPA National Library Catalog


Main Title Use of Radioligand Binding Techniques in Neurotoxicology.
Author DeHaven, D. L. ; Mailman, R. B. ;
CORP Author North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/D-85/164;
Stock Number PB86-128766
Additional Subjects Toxicology ; Ligands ; Binding ; Neurotoxicology ; Radioligands
Library Call Number Additional Info Location Last
NTIS  PB86-128766 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 50p
Although it had been suggested that chemical transmission was an important physiological mechanism, confirmation awaited Loewi's finding that autonomic nerve impulses resulted in the release of specific chemical stimulants. These results led to an inevitable conclusion--that there must be specific recognition sites that can respond to the presence of the minute amounts of these chemical transmitters. In the intervening years, it became clear that the interaction of a ligand (e.g., a chemical transmitter) with a binding site (e.g., a receptor) could be characterized not only physiologically, but also biochemically. However, the available biochemical methods required relatively large amounts of tissue containing the receptors, especially considering the low concentration of receptors in the nervous system.