Record Display for the EPA National Library Catalog


Main Title Pyrethroid Insecticides and Radioligand Displacement from the GABA Receptor Chloride Ionophore Complex.
Author Crofton, K. M. ; Reiter, L. W. ; Mailman, R. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Year Published 1987
Report Number EPA/600/J-87/050;
Stock Number PB87-212445
Additional Subjects Insecticides ; Toxicology ; Rats ; Ligands ; Synapses ; Hazardous materials ; Reprints ; Pyrethrins ; Neurotoxins ; Receptors(Gaba-benzodiazepine) ; FLU(Flunitrazepam) ; TBPS(t-butylbicyclophosphorothionate) ; MUS(Muscimol)
Library Call Number Additional Info Location Last
NTIS  PB87-212445 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Radioligand binding displacement studies were conducted to determine the effects of Type I and II pyrethroids on (3H)-flunitrazepam (FLU), (3H)-muscimol (MUS), and (35S)t-butylbicyclophosphorothionate (TBPS) binding. Competition experiments with (3H)-FLU and (3H)-MUS indicate a lack of competition for binding by the pyrethroids. Type I pyrethroids failed to compete for the binding of (35S)-TBPS at concentrations as high as 50 pM. Type II pyrethroids inhibited (35S)-TBPS binding to rat brain synaptosomes with Ki values ranging from 5-10 pM. The data presented here suggest that the interaction of Type II pyrethroids with the GABA receptor-ionophore complex is restricted to a site near the TBPS/picrotoxinin binding site.