Record Display for the EPA National Library Catalog


Main Title Neurotoxicants and Membrane-Associated Functions.
Author Mailman, R. B. ; Morell, P. ;
CORP Author North Carolina Univ. at Chapel Hill. Biological Sciences Research Center.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/D-85/163;
Stock Number PB87-186318
Additional Subjects Toxicology ; Nervous system ; Membranes ; Methodology ; Exposure ; Abnormalities ; Biochemistry ; Perturbation ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB87-186318 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 47p
The goal of the review is to describe methods available for use by research workers interested in studying the site and/or mode of action of compounds that might perturb the function of membranes in the nervous system. Many, or even most, neurotoxic agents may eventually bring about some perturbation of membrane structure, composition, or function. It is difficult to differentiate those changes mediating, from those compensating for, toxic insults. The review is limited to a discussion of certain approaches and methodologies believed to be important for studying these problems. Some examples of how these biochemical approaches may be used to define membrane-related abnormalities subsequent to exposure to a toxin are also given. Emphasis is placed on those methodologies and results that may be related to neurotransmission.