Record Display for the EPA National Library Catalog


Main Title Effects of Trimethyltin on Dopaminergic and Serotonergic Function in the Central Nervous System.
Author DeHaven, D. L. ; Walsh, T. J. ; Mailman, R.B. ;
CORP Author North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-R-809644; EPA/600/J-84/328;
Stock Number PB86-117231
Additional Subjects Central nervous system ; Toxicology ; Brain ; Dopamine ; Serotonin ; Rats ; Laboratory animals ; Reprints ; Tin/trimethyl ; Metabolites
Library Call Number Additional Info Location Last
NTIS  PB86-117231 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
The effects of trimethyltin (TMT) administration on regional concentrations of dopamine (DA), serotonin (5-HT), and their metabolites were determined. Acute administration of 3 or 7 mg/kg TMT (as the chloride) to adult male Long-Evans rats caused alterations in both dopaminergic and serotonergic function in brain at 7 days posttreatment. Dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were decreased in the nucleus accumbens of rats treated with 7 mg/kg, with a trend occurring with the 3-mg/kg dose group. Conversely, concentrations of DA or DOPAC were not altered in striatum, olfactory tubercle, septum, or amygdala/pyriform cortex. Administration of 3 mg/kg TMT decreased the concentration of serotonin in striatum and nucleus accumbens, and increased the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in hippocampus. The 7-mg/kg dose resulted in increased concentrations of 5-HIAA in striatum, nucleus accumbens, septum, amygdala/pyriform cortex, and hippocampus, and also decreased the concentration of 5-HT only in amygdala/pyriform cortex.