Record Display for the EPA National Library Catalog


Main Title Effects of Postnatal Trimethyltin or Triethyltin Treatment of CNS Catecholamine, GABA (Gamma-Aminobutyric Acid), and Acetylcholine Systems in the Rat.
Author Mailman, R. B. ; Krigman, M. R. ; Frye, G. D. ; Hanin, I. ;
CORP Author North Carolina Univ. at Chapel Hill. School of Medicine. ;Pittsburgh Univ., PA. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-R-809644; EPA/600/J-83/310;
Stock Number PB86-117223
Additional Subjects Tin ; Toxicity ; Brain ; Rats ; Neurochemistry ; Damage ; Hippocampus ; Ammino compounds ; Butyric acid ; Metabolism ; Behavior ; Reprints ; Trimethyltin sulfate ; Trimethyltin hydroxide ; Dopamine
Library Call Number Additional Info Location Last
NTIS  PB86-117223 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
The effects on brain neurochemistry of two neurotoxic tin compounds, trimethyltin (TMT) hydroxide and triethyltin (TET) sulfate, were examined. Long-Evans rats were treated with TMT hydroxide (1 mg/kg, i.p.) on alternate days from day 2 to 29 of life. These treatments caused a weight deficit of 10-20% by the time the animals were killed on day 55 by head-focused microwave irradiation. These TMT treatments are known to cause severe neuronal loss in the hippocampus and lesser damage in other brain regions. (Copyright (c) 1983 International Society for Neurochemistry.)