Record Display for the EPA National Library Catalog


Main Title Studies on the Safety of DDVP for the Disinsection of Commercial Aircraft.
Author Witter, Robert F. ; Gaines, Thomas B. ; Short, J. Gordon ; Sedlak, V. A. ; Maddock., D. R. ;
CORP Author Communicable Disease Center, Savannah, Ga.
Year Published 1961
Stock Number PB-277 612
Additional Subjects Insecticides ; Pesticides ; Toxicology ; Toxicity ; Phosphorus organic compounds ; Humans ; Monkeys ; Exposure ; Laboratory animals ; Experimental data ; Aircraft ; Concentration(Composition) ; Cholinesterase inhibitors ; Bioassay ; Reprints ; Toxic hazards ; Toxic substances ; DDVP insecticide
Library Call Number Additional Info Location Last
NTIS  PB-277 612 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
There is a need for a more effective method for the disinsection of intercontinental aircraft. A study was made of the possible toxic hazard associated with a new method of disinsection using DDVP vapour (O,O-dimethyl-2,2-dichlorovinyl phosphate) as the insecticidal agent. In these experiments, men and monkeys were exposed four times over one- or two-hour periods for a total of 4-8 hours to DDVP vapour in a simulated aircraft cabin. The concentration of DDVP was higher and the exposure periods were longer than those planned for use in disinsection. Concentrations up to 0.7 micrograms per litre of air produced no effect on the cholinesterase of men or monkeys. It was found that a concentration of DDVP of 0.9-3.5 microgram per litre of air caused a slight decrease in plasma cholinesterase of the men and the monkeys. At a DDVP concentration of 7.5-17.9 microgram per litre, monkeys exhibited a marked drop in red cell and plasma cholinesterase and showed miosis, but no other signs of poisoning.