Record Display for the EPA National Library Catalog


Main Title Toluene Levels in Blood and Brain of Rats as a Function of Toluene Level in Inspired Air.
Author Benignus, V. A. ; Muller, K. E. ; Graham, J. A. ; Barton, C. N. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ., Chapel Hill.
Year Published 1984
Report Number EPA/600/J-82-010;
Stock Number PB84-197532
Additional Subjects Toluene ; Toxicology ; Blood ; Brain ; Rats ; Laboratory animals ; Reprints ; Air pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB84-197532 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
The relationship of toluene concentration in blood and brain to the concentration of toluene in inspired air has not been explicitly studied. Sixty rats were exposed by inhalation to 50, 100, 500, or 1000 ppm toluene for 3 hr. Immediately following exposure, venous blood samples and whole brains were collected and assayed for toluene levels. For several empirical reasons, the natural logarithm (log) of toluene tissue levels were predicted in a linear model from log toluene levels in air. An additional 10 rats were exposed to 550 ppm toluene for 8 hr in order to verify that the 3-hr exposure was sufficient to produce near-asymptotic levels of toluene in blood and brain. Log brain toluene concentration was significantly higher than log blood concentration by an additive constant. The ration of brain to blood toluene level was estimated as 1.56/1. Three- and eight-hour exposure results did not differ, thus indicating that these results would hold for toluene exposures of 3 hr or greater.