Record Display for the EPA National Library Catalog


Main Title Toluene Blood Level following Subcutaneous Injection of Toluene in the Rat.
Author Benignus, V. A. ; Muller, K. E. ; Barton, C. N. ; Bittikofer, J. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. Dept. of Psychology. ;Duke Univ. Medical Center, Durham, NC. Clinical Chemistry Lab.
Year Published 1984
Report Number EPA/600/J-84/144;
Stock Number PB85-124527
Additional Subjects Toluene ; Bioassay ; Toxicology ; Rats ; Laboratory animals ; Blood chemical analysis ; Dosage ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB85-124527 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
A model of toluene level in blood following subcutaneous injection of toluene mixed with polyoxyethylated-vegetable-oil vehicle was developed. The purpose was to provide a means of predicting dose received for subsequent toxicologic studies for any time and dose combination. The pharmacokinetics were of secondary interest. Using data from 111 rats, a four-parameter equation was devised to predict the time course of toluene blood level from 20-480 min post dosing, for dose levels of 50-1000 mg/kg. Blood concentrations rose at a rate which was independent of dose level. Maximum blood levels were uniquely determined by dose level. Blood levels fell at different rates depending upon dose level. Injection exposure, when compared to inhalation, has the advantages of (a) low expense, (b) low equipment requirements, and (c) simplicity. The disadvantage is, for some experiments, poor temporal simulation of the normal route of administration, inhalation.