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Main Title Uptake, excretion, and physiological effects of hexachlorobenzene in growing lambs /
Author Mull, Ronald L. ; Winterlin, Wray L. ; Peoples., Stuart A.
Other Authors
Author Title of a Work
Mull, Ronald L.
Winterlin, Wray L.
Peoples, S. A.
CORP Author California Univ., Davis. Food Protection and Toxicology Center.;Environmental Protection Agency, Washington, D.C. Office of Toxic Substances.
Publisher U.S. Environmental Protection Agency,
Year Published 1976
Report Number EPA/560/6-76/013; EPA-68-01-2254
Stock Number PB-276 480
Subjects Hexachlorobenzene--Physiological effect. ; Hexachlorobenzene--Physiological effects
Additional Subjects Chlorobenzenes ; Pesticides ; Toxicity ; Ingestion(Biology) ; Metabolism ; Excretion ; Absorption(Biology) ; Food contamination ; Sheep ; Bioassay ; Dosage ; Dose rate ; Growth ; Toxicity ; Hematology ; Enzymes ; Biochemistry ; Physiological effects ; Pathology ; Histology ; Tables(Data) ; Lindane ; Toxic substances ; Bioaccumulation ; Chlorobenzene/hexa ; Pesticide residues ; Pharmacokinetics ; Environmental health
Library Call Number Additional Info Location Last
NTIS  PB-276 480 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 volume (various pagings) ; 28 cm
Growing lambs were exposed to daily doses of hexachlorobenzene (HCB) per os. The daily dose was calculated to provide 0.01, 0.10 or 1.00 ppm of the feed consumed. Exposure was terminated at 90 days and 20 of the 50 lambs were slaughtered. Remaining lambs were monitored for an additional 210 days. At the end of the 90 day exposure, the in vivo metabolism of aminopyrine and the in vitro O and N-demethylation of the liver microsomes were determined. Results of the analyses for HCB in omental fat show that the peak concentration attained was 10.186, 1.024, 0.116 and 0.012 ppm in the 1.00, 0.10, 0.01 ppm and control groups respectively. Following cessation of the exposure, the HCB declined to less than one-half the peak concentration within 100 days. Histological examination of tissues from the slaughtered animals showed no pathological changes attributable to the HCB. Marked changes were noted in the microsomal enzymes but changes were not significant in the plasma enzymes.