Record Display for the EPA National Library Catalog


Main Title Acute and Subchronic Inhalation Exposures of Hamsters to Nickel-Enriched Fly Ash.
Author Wehner, Alfred P. ; Moss, Owen R. ; Milliman, Edward M. ; Dagle, Gerald E. ; Schirmer, Roger E. ;
CORP Author Battelle Pacific Northwest Labs., Richland, WA. Biology Dept.;Health Effects Research Lab., Cincinnati, OH.
Year Published 1981
Report Number EPA-68-03-2457; EPA-600/J-79-125;
Stock Number PB81-201147
Additional Subjects Fly ash ; Toxicology ; Nickel ; Respiration ; Exposure ; Hamsters ; Laboratory animals ; Concentration(Composition) ; Aerosols ; Lung ; Reprints ; Air pollution effects(Animals) ; Toxic substances ; NTISEPAORD
Library Call Number Additional Info Location Last
NTIS  PB81-201147 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 18p
One 6-hr inhalation exposure of hamsters to Ni-enriched fly ash (NEFA) aerosol (respirable aerosol concentration approx. 200 micrograms/liter) deposited about 80 micrograms in the deep lung, of which 75 micrograms was still present 30 days postexposure. The animals tolerated the exposure well during the 30-day postexposure observation period. Two-month exposures of hamsters to NEFA or fly ash (FA) aerosols (approx. 185 micrograms/liter) resulted in a deep lung burden of about 5.7 mg, dark discoloration of lungs, heavily dust-laden macrophages, and significantly higher lung weights than in controls, but only minimal inflammatory reaction and no deaths. There was no difference between NEFA and FA effects. The NEFA contained 9% Ni; FA contained 0.03% Ni. The results of this study indicate low acute and subchronic toxicity and slow lung clearance of NEFA and FA.