Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Differential Effects of Formamidine Pesticides on Fixed-Interval Behavior in Rats.
Author Moser, V. C. ; MacPhail, R. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/159;
Stock Number PB87-118527
Additional Subjects Toxicology ; Pesticides ; Rats ; Behavior ; Laboratory animals ; Formamidine ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB87-118527 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 12p
Chlordimeform (CDM), amitraz (AMZ), and formetanate (FMT) are members of the formamidine class of pesticides. To date, effects on operant behavior have been determined only for CDM. The experiment compared the effects of CDM, AMZ, and FMT on schedule-controlled responding. Nine male Long-Evans rats were trained during 1-hr sessions to lever-press under a multiple fixed-interval (FI)-1-min FI-5-min schedule of milk reinforcement. Dose-effect determinations for each compound administered ip, 20 min presession, were carried out in each subject. The dose ranges were: CDM HCl, 0.3-20 mg/kg; FMT HCl, 0.03-0.75 mg/kg; and AMZ, 5-75 mg/kg. Under baseline conditions response rates were higher under the FI-1-min than under FI-5-min, and index of curvature (IOC) values (a measure of within-interval response patterning) were generally higher under FI-5-min. All compounds produced dose-dependent decreases in response rate. CDM significantly decreased only FI-1-min response rates; a similar effect of AMZ was seen only at an intermediate dose. FMT decreased responding to the same extent in both components. CDM produced pronounced changes in the pattern of responding in both components, with IOC decreased more under FI-5-min than under FI-1-min. AMZ produced significant decreases in IOC only under FI-5-min. FMT did not appreciably decrease IOC in either component.