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Main Title Lung Tumor Induction in Strain a Mice with Benzotrichloride (Journal Version).
Author Stoner, G. D. ; You, M. ; Morgan, M. A. ; Superczynski, M. J. ;
CORP Author Medical Coll. of Ohio at Toledo. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1986
Year Published 1986
Report Number EPA/600/J-86/471;
Stock Number PB89-104012
Additional Subjects Toxic substances ; Toxicity ; Carcinogens ; Occupational safety and health ; Lung neoplasms ; Laboratory animals ; Dose-response relationships ; Chlorine organic compounds ; Reprints ; Benzotrichloride ; Benzene/trichloromethyl
Library Call Number Additional Info Location Last
NTIS  PB89-104012 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Benzotrichloride (BTC) is used in the synthesis of benzoyl chloride and benzoyl peroxide. Epidemiological data suggest that BTC is a human lung carcinogen. In the present study, BTC was evaluated for its ability to induce lung adenomas in strain A/J mice. Four groups of 15 male and 15 female A/J mice were injected i.p. with either tricaprylin or BTC in tricaprylin three times a week for 8 weeks. BTC groups received doses totaling 1440 mg/kg, 719 mg/kg or 287 mg/kg. The mean number of lung tumors per mouse was 127 87 plus or minus 5.81, 43 plus or minus 2.44, and 17.73 plus or minus 1.09 in the groups treated with either 1440 mg/kg, 719 mg/kg, or 287 mg/kg, respectively. Tricaprylin-vehicle controls had a mean number of 0.46 plus or minus 0.15 lung tumors per mouse. Therefore, BTC produced a significant (P<0.001) and dose-related increase in the lung tumor response when compared to tricaprylin controls and is a potent carcinogen in the strain A mouse lung tumor bioassay. (Copyright (c) 1986 Elsevier Scientific Publishers Ireland Ltd.)