Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Airway Structure Variability in the Long-Evans Rat Lung.
Author Menache, M. G. ; Patra, A. L. ; Miller, F. J. ;
CORP Author Northrop Services, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA-68-02-4450; EPA/600/J-91/311;
Stock Number PB92-124676
Additional Subjects Trachea ; Lung ; Anatomy ; Rats ; Statistical analysis ; Particles ; Reprints ; Intra-animal variability ; Inter-animal variability
Library Call Number Additional Info Location Last
NTIS  PB92-124676 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 02/24/1992
Collation 9p
Mathematical models used to study deposition of inhaled toxicants require morphometric data to represent the tracheobronchial airways of laboratory animals. Because of the difficulty and cost of obtaining detailed measurements, morphometric models are generally based on measurements from a small number of specimens. To determine the degree of interanimal variability among laboratory animals of the same strain and size, lengths and diameters of the same 200 airways were measured in solid casts in each of 10 male Long-Evans rats. Intraanimal variability was substantially greater than interanimal variability for airway lengths and diameters. Intraanimal variability was reduced when the airways were grouped so that airway generations were adjusted for lobar position. The study results suggest that detailed measurements of the conducting airways in a small number of casts with summarization techniques that retain lobar information will provide a less variable estimate of lung geometry than a smaller number of measurements made in several casts.