Record Display for the EPA National Library Catalog


Main Title Extrapulmonary Effects of NO2 as Reflected by Pentobarbital-Induced Sleeping Time in Mice.
Author Miller, Frederick J. ; Graham, Judith A. ; Illing, Joseph W. ; Gardner, Donald E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1980
Report Number EPA-600/J-80-254;
Stock Number PB81-192072
Additional Subjects Nitrogen dioxide ; Pentobarbital ; Toxicology ; Barbiturates ; Mice ; Laboratory animals ; Exposure ; Sleep ; Concentration(Composition) ; Males ; Females ; Reprints ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB81-192072 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
The influence of nitrogen dioxide (NO2) on pentobarbital(PEN)-induced sleeping time (S.T.) was investigated in mice. Acute exposure to concentrations as low as 470 micrograms NO2/cu m (0.25 ppm) caused a significant increase in PEN-induced S.T. No significant effects on PEN-induced S.T. were detected after 1 or 2 days (3 h/day) exposure to 235 micrograms NO2/cu m (0.125 ppm). None of the exposure regimens affected the time required for the drug to induce sleep. When the effects of repeated daily exposures (3 h/day) to 9400 micrograms NO2/cu m 5 ppm) were compared in male and female mice, the females had a significantly increased PEN-induced S.T. after 1 and 2 days of exposure. However, an increase in PEN-induced S.T. was not observed in males until the 3rd day of exposure. Since the duration of PEN-induced S.T. is primarily determined by hepatic mixed function oxidase activity, it is possible that NO2 may alter some aspects of xenbiotic metabolism.