Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Chemically Induced Maternal Toxicity on Prenatal Development in the Rat.
Author Chernoff, N. ; Setzer, R. W. ; Miller, D. B. ; Rosen, M. B. ; Rogers, J. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;Northrop Services, Inc., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-92/074;
Stock Number PB92-150887
Additional Subjects Teratogens ; Toxicity ; Fetal development ; Maternal-fetal exchange ; Diquat ; Toxaphene ; Styrene ; Organotin compounds ; Cacodylic acid ; Dose-response relationships ; Reprints ; Rats ; Supernumerary ribs ; Ethylene-bis-isothiocyanate ; Dichlorophenoxyacetic acids ; Trichlorophenols
Library Call Number Additional Info Location Last
NTIS  PB92-150887 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/28/1992
Collation 10p
The hypothesis that chemically induced overt maternal toxicity induces a characteristics syndrome of adverse developmental effects in the rat was investigated. Pregnant animals (Sprague-Dawley strain) were dosed by oral gavage with one of a series of compounds on days 6-15 of gestation. These chemicals were diquat (DIQ), ethylene-bis-isothiocyanate (EBIS), toxaphene (TOX), styrene (STY), 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenol (2,4,5-Tr), triphenyl tin hydroxide (TPTH), and cacodylic acid (CAC). Significant maternal weight reductions were noted during the course of treatment with all compounds except CAC and 2,4,5-Tr. Maternal lethality was produced by EBIS, TOX, 2,4,-D, and 2,4,5-Tr. The main treatment-related developmental toxicity noted in litters at term consisted of increased lethality (EBIS, TPTH) and decreased fetal weight (EBIS and CAC). Treatment-related anomalies were seen in litters treated with 2,4-D and TOX (supernumerary ribs) and with EBIS and STY (enlarged renal pelvis). No significant developmental effects were produced with DIQ, or 2,4,5-Tr. The study indicates that overt maternal toxicity as defined by weight loss or mortality is not always associated with the same defined syndrome of adverse developmental effects in the rat.