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Main Title Effects of Chemically Induced Maternal Toxicity on Prenatal Development in the Rat.
Author Chernoff, N. ; Setzer, R. W. ; Miller, D. B. ; Rosen, M. B. ; Rogers, J. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;Northrop Services, Inc., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-92/074;
Stock Number PB92-150887
Additional Subjects Teratogens ; Toxicity ; Fetal development ; Maternal-fetal exchange ; Diquat ; Toxaphene ; Styrene ; Organotin compounds ; Cacodylic acid ; Dose-response relationships ; Reprints ; Rats ; Supernumerary ribs ; Ethylene-bis-isothiocyanate ; Dichlorophenoxyacetic acids ; Trichlorophenols
Library Call Number Additional Info Location Last
NTIS  PB92-150887 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
The hypothesis that chemically induced overt maternal toxicity induces a characteristics syndrome of adverse developmental effects in the rat was investigated. Pregnant animals (Sprague-Dawley strain) were dosed by oral gavage with one of a series of compounds on days 6-15 of gestation. These chemicals were diquat (DIQ), ethylene-bis-isothiocyanate (EBIS), toxaphene (TOX), styrene (STY), 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenol (2,4,5-Tr), triphenyl tin hydroxide (TPTH), and cacodylic acid (CAC). Significant maternal weight reductions were noted during the course of treatment with all compounds except CAC and 2,4,5-Tr. Maternal lethality was produced by EBIS, TOX, 2,4,-D, and 2,4,5-Tr. The main treatment-related developmental toxicity noted in litters at term consisted of increased lethality (EBIS, TPTH) and decreased fetal weight (EBIS and CAC). Treatment-related anomalies were seen in litters treated with 2,4-D and TOX (supernumerary ribs) and with EBIS and STY (enlarged renal pelvis). No significant developmental effects were produced with DIQ, or 2,4,5-Tr. The study indicates that overt maternal toxicity as defined by weight loss or mortality is not always associated with the same defined syndrome of adverse developmental effects in the rat.