Main Title |
Influence of Ozone and Nitrogen Dioxide on Hepatic Microsomal Enzymes in Mice. |
Author |
Graham, J. A. ;
Miller, F. J. ;
Gardner, D. E. ;
Ward, R. ;
Menzel, D. B. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;Duke Univ., Durham, NC. |
Year Published |
1982 |
Report Number |
EPA-600/J-81-310; |
Stock Number |
PB84-173137 |
Additional Subjects |
Ozone ;
Nitrogen dioxide ;
Enzymes ;
Toxicology ;
Mice ;
Laboratory animals ;
Microsomes ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-173137 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Since ambient concentrations of ozone and nitrogen dioxide increase drug-induced sleeping time in female mice, potential mechanisms were sought by investigating the effects of these gases on hepatic microsomal mixed-function oxidases in female CD-1 mice. Exposure to ozone did not change the concentration of cytochrome P-450 significantly. Aniline hydroxylase, but not aminopyrine N-demethylase or p-nitroanisole O-demethylase, activities were increased following exposure. Aniline hydroxylase activity was also increased after exposure. In these studies, ozone sometimes increased wet liver weight, and thus additional experiments were conducted. Exposure to ozone caused a lesser decrease in body weight than the decrease observed after a similar air exposure. Liver wet weights were elevated after ozone exposure. From these data, it is concluded that mechanisms other than those investigated are responsible for the effect of ozone and nitrogen dioxide on drug-induced sleeping time. |