Record Display for the EPA National Library CatalogRECORD NUMBER: 8 OF 25
|Main Title||Comparative Toxicity of Azinphos-Methyl to House Mice, Laboratory Mice, Deer Mice, and Gray-Tailed Voles.|
|Author||Meyers, S. M. ; Wolff, J. O. ;|
|CORP Author||ManTech Environmental Technology, Inc., Corvallis, OR. ;Oregon State Univ., Corvallis. Dept. of Fisheries and Wildlife.;Corvallis Environmental Research Lab., OR.|
|Report Number||EPA-68-C8-0006; EPA/600/J-94/272;|
|Additional Subjects||Toxicity ; Pesticides ; Insecticides ; Risk assessment ; Mice ; Dosage ; Mortality ; Body weight ; Field tests ; Oral administration ; Acute exposure ; Lethal doses ; Cholinesterase ; Reprints ; Azinphos-methyl ; Guthion ; Mus musculus ; Microtus canicaudus ; Peromyscus maniculatus ; Voles|
The authors conducted a laboratory toxicity study on house mice and laboratory mice, gray-tailed voles, and deer mice as part of a comprehensive laboratory and field study to field-validate laboratory-based risk assessment of argichemicals. The single dose oral LD50 for the organophosphorus insecticide azinphos-methyl was 10, 11, 32, 48 mg/kg body mass in wild house mice, laboratory mice, gray-tailed voles, and deer mice, respectively. The authors conclude that (1) laboratory mice were not representative of deer mice or gray-tailed voles with respect to sensitivity to the pesticide, but provided a conservative estimates for risk assessment; (2) 5-d dietary LC50 tests provide substantially higher estimates of toxicity to rodents than do 10-d test; and (3) ChE depression of 45 to 50% was lethal.