TERRE-TOX is a new data base developed for the U.S. Environmental Protection Agency to aid in evaluating pre-manufacturing notices and research. TERRE-TOX contains published (1970 to present) information on toxicity of anthropogenic substances to terrestrial animals. Currently, species are limited to wildlife, bees, earthworms, and laboratory rodents where the substance involved is likely to affect wildlife. The studies deal with acute toxicity, behavior, reproduction, physiological and biochemical responses. Additional information on the chemical used for each study (CAS number, purity, synonyms), test organisms (species, common name, age), and test conditions (route of administration, dose regimen, range of doses) is also provided. TERRE-TOX is designed to become part of SPHERE (Scientific Parameters for Health and Environment, Retrieval and Estimation) within the Chemical Information System.