Main Title |
Dose Response of Elastase-Induced Emphysema in Hamsters. |
Author |
Raub, James A. ;
Mercer, Robert R. ;
Miller, Frederick J. ;
Graham, Judith A. ;
O'Neil, John J. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1981 |
Report Number |
EPA-600/J-81-332; |
Stock Number |
PB82-248048 |
Additional Subjects |
Emphysema ;
Respiratory diseases ;
Toxicology ;
Hamsters ;
Laboratory animals ;
Air pollution ;
Reprints ;
Pancreatopeptidase ;
Air pollution effects(Animals) ;
Lung function tests
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB82-248048 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
Elastase-induced emhysema in hamsters was studied using pulmonary function tests in an effort to develop techniques for determining the effects of air pollutants on the progression of this disease. It appears that as little as 6 units of elastase produces mild emphysema in hamsters, which is detectable by pulmonary function testing. Of the tests, the DLCO and N2 slope were the most effective in detecting the degree of impairment. |