Record Display for the EPA National Library Catalog


Main Title Inhalation Studies of Mt. St. Helens Volcanic Ash in Animals: Respiratory Mechanics, Airway Reactivity and Deposition.
Author Wiester, M. J. ; Setzer, C. J. ; Barry, B. E. ; Mercer, R. R. ; Grady, M. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. Dept. of Pathology.
Year Published 1985
Report Number EPA/600/J-85/024;
Stock Number PB85-198851
Additional Subjects Toxicology ; Volcanic ejecta ; Deposition ; Respiration ; Guinea pigs ; Histamine receptors ; Air pollution effects(Animals) ; Inhalation provocation tests
Library Call Number Additional Info Location Last
NTIS  PB85-198851 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Effects of fine volcanic ash aerosol on pulmonary mechanical properties of awake guinea pigs were evaluated during exposure by inhalation. Ash penetration into the lungs as well as tissue response to ash were determined by transmission electron microscopy. The reactivity of airway epithelial irritant receptors following ash exposure was assessed using a histamine bronchoprovocation test. It appears that even though Mt. St. Helens ash was well tolerated by the guinea pig during the exposure, its presence in the inhaled air did change the 'histamine sensitivity' of airway epithelial irritant receptors.