Record Display for the EPA National Library Catalog


Main Title Inhalation Studies of Mt. St. Helens Volcanic Ash in Animals. 2. Lung Function, Biochemistry, and Histology.
Author Raub, J. A. ; Hatch, G. E. ; Mercer, R. R. ; Grady, M. ; Hu, P. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/129;
Stock Number PB86-100211
Additional Subjects Toxicology ; Volcanic ejecta ; Respiration ; Lung ; Sulfur dioxide ; Rats ; Laboratory animals ; Reprints ; Mount St Helen ; Air pollution effects(Animals) ; Inhalation provocation tests
Library Call Number Additional Info Location Last
NTIS  PB86-100211 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Rats were exposed by inhalation to 9.4 mg/m3 size-fractionated volcanic ash for 5 days (2hr/day) and examined for changes in pulmonary function and histology for periods of up to 1 year. Fine-mode volcanic ash, SO2, and a combination of ash and SO2 produced no observable effects in normal rats and rats with elastase-induced emphysema. However, there was a mild irritant response to SO2 which was not influenced by the volcanic ash. Rats injected intratracheally with fine-mode volcanic ash or saline showed no evidence of pulmonary alterations after 6 months. Those injected with coarse-mode volcanic ash showed minor pulmonary functional changes, histologically detectable alveolitis, and small increases in lung weight. In contrast, quartz-injected rats showed large alterations in pulmonary function, lung weight, hydroxyproline levels, and large areas of lung consolidation and fibrosis. (Copyright (c) 1985, Academic Press, Inc.)