Record Display for the EPA National Library Catalog


Main Title Effect of Ozone on Drug-Induced Sleeping Time in Mice Pretreated with Mixed-Function Oxidase Inducers and Inhibitors.
Author Graham, Judith A. ; Menzel, Daniel B. ; Miller, Frederick J. ; Illing, Joseph W. ; Gardner, Donald E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-80-100;
Stock Number PB82-247255
Additional Subjects Sleep ; Ozone ; Pentobarbital ; Toxicology ; Barbiturates ; Mice ; Rats ; Hamsters ; Laboratory animals ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB82-247255 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Studies were conducted to investigate the effect of ozone in prolonging pentobarbital (PEN)-induced sleeping time (S.T.). Since ozone is a common air pollutant, an ozone-induced alteration of mechanisms of drug action could have public health implications. It was shown that a 5-hr exposure to 1960 micrograms ozone/cu. m. (1 ppm) caused an increased PEN-induced S.T. in female mice (three strains), rats, and hamsters. This response was not observed in male rats or in male mice even when the latter were exposed for 5 hr/day for 3 days. Male hamsters were affected, but less so than females. These data are interpreted as a systemic effect of ozone on mechanisms of the termination of action of pentobarbital.