Record Display for the EPA National Library Catalog


Main Title Predicted Deposition of Nonhygroscopic Aerosols in the Human Lung as a Function of Subject Age.
Author Hofmann, W. ; Martonen, T. B. ; Graham, R. C. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Center for Extrapolation Modelling.;Salzburg Univ. (Austria).;Health Effects Research Lab., Research Triangle Park, NC. Inhalation Toxicology Div.
Publisher c4 May 88
Year Published 1988
Report Number EPA-68-02-4450; EPA/600/J-89/470;
Stock Number PB91-109587
Additional Subjects Aerosols ; Mathematical models ; Children ; Lungs ; Toxicology ; Public health ; Respiratory system ; Deposition ; Particle size ; Respiration ; Reprints ; Inhalation ; Air pollution effects(Humans) ; Age factors
Library Call Number Additional Info Location Last
NTIS  PB91-109587 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 22p
A predictive aerosol deposition model, which has been validated by comparison with experimental data from adult test subjects, is used to study particle deposition patterns within the developing human lung. Here, an age-dependent lung morphology is presented in which the growth of bronchial airway dimensions is described by the measurements of Phalen et al. (1985), and the number and sizes of pulmonary airways are derived from Dunnill (1962). Total tracheobronchial, and pulmonary deposition fractions are calculated for different breathing patterns, from sedentary to maximal activity, and particle sizes, ranging over three orders of magnitude. The influences of human subject age and physical activity levels upon regional aerosol deposition within the developing lung are complex; systematic patterns, however, can be identified which are consistent with the effects of linear airway dimensions and particle flow characteristics upon effective particle deposition mechanisms.