The Public Health Service Air Pollution Medical and Air Pollution Engineering Programs have conducted a joint study of air pollution in Nashville, Tennessee, with the School of Medicine of Vanderbilt University. Objectives of the study were to investigate possible relationships between air pollution and the health of people and to obtain information on a number of aspects of the engineering and meteorological aspects of air pollution. The four phases of the medical study are described. They include a morbidity survey, a mortality survey, a clinical study of individuals with known chronic cardiorespiratory disease, and an anthracosis study of autopsied individuals. The extensive aerometric studies are described in terms of objectives and equipment and methods used. General descriptive information concerning the study area is presented. (Author)