Record Display for the EPA National Library Catalog


Main Title Investigation of the metabolism of chlorinated hydrocarbons in subhuman species /
Author Smith, C. C. ; Cragg, S. T. ; Wolfe, G. F. ; Weigel, W. W.
Other Authors
Author Title of a Work
Smith, Carl C.
Cragg, Steven T.
Wolfe, Geraldine F.
Weigel, Walter W.
Lingg, Robert.
CORP Author Cincinnati Univ., OH. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1985
Report Number EPA-600/1-85-001; EPA-R-803963
Stock Number PB85-152387
OCLC Number 58675300
Subjects Drinking water--Contamination--United States ; Chlorine--Physiological effect
Additional Subjects Potable water ; Metabolism ; Chlorine organic compounds ; Research projects ; Toxicity ; Laboratory animals ; Dosage ; Benzene/trichloro ; Methane/bromo-dichloro ; Ether/bis(chloroisopropyl) ; Ether/bis(chloroethyl) ; Pharmacokinetics
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
ELBD  EPA 600-1-85-001 AWBERC Library/Cincinnati,OH 03/31/2005
NTIS  PB85-152387 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xiii, 119 p. : ill. ; 28 cm.
The purpose of this research program was to provide metabolic data on four rather common drinking water contaminants. The compounds were 1,2,4-trichlorobenzene (TCB), bromodichloromethane (BDC), bis(2-chloroisopropyl) ether (BCIE) and bis(2-chloroethyl) ether (BCEE). The compounds, labeled with 14C, were administered orally and sometimes intravenously, to rats and rhesus monkeys. Studies on TCB included excretion and tissue distribution in rats, pharmacokinetic studies in monkeys and subchronic studies in monkeys. Daily oral doses of 174 mg/kg were uniformly fatal to monkeys in less than one month. Activity of liver enzymes was increased. Pharmacokinetics and tissue distribution of BDC was examined in rats and monkeys. The compound was excreted primarily via the lung either unchanged or as CO2. BCIE in monkeys was also excreted via the lung and was very toxic to the eyes and kidneys following multiple 30 mg/kg oral doses. Preliminary studies of BCEE in two rhesus monkeys produced the same signs of periorbital toxicity as BCIE when oral doses of 10 mg/kg were administered.
"PB85-152387." "Grant #R-803963." "Project Officer, Robert Lingg." "January 1985." "EPA-600/1-85-001."