Record Display for the EPA National Library Catalog


Main Title Morphological Changes in Livers of Rats Fed Polychlorinated Biphenyls, Light Microscopy and Ultrastructure.
Author Kimbrough, Renate D. ; Linder, Ralph E. ; Gaines., Thomas B. ;
CORP Author Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs.
Year Published 1972
Stock Number PB-279 729
Additional Subjects Pesticides ; Toxicology ; Bioassay ; Chlorine organic compounds ; Dosage ; Rats ; Experimental data ; Laboratory animals ; Liver ; Diet ; Ingestion(Biology) ; Pathology ; Tables(Data) ; Body weight ; Histology ; Reprints ; Toxic substances ; Aroclor 1254 ; Aroclor 1260 ; Biphenyl/chloro
Library Call Number Additional Info Location Last
NTIS  PB-279 729 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Male and female Sherman strain rats were fed polychlorinated biphenyls Aroclor 1260 and Aroclor 1254 at 0, 20, 100, 500 and 1,000 ppm in their diet. Rats received the dietary levels for eight months. Light microscopic changes consisted of hypertrophy of the liver cells, inclusions in the cytoplasm, brown pigment in Kupffer cells, lipid accumulation, and, at the higher dietary levels, adenofibrosis. Ultrastructural changes of the livers of exposed animals consisted of an increase in smooth endoplasmic reticulum and atypical mitochondria. Lipid vacuoles were occasionally surrounded by concentric membranes. The epithelial component of adenofibrosis consisted of goblet cells and cells that resembled the epithelium which lines the bile ducts. In general, the effect of Aroclor 1254 on the liver was more pronounced than that of Aroclor 1260.