Record Display for the EPA National Library Catalog


Main Title Liver Metabolism of Anticholinesterase Compounds in Live Rats: Relation to Toxicity.
Author Gaines, Thomas B. ; Hayes, Jr., Wayland J. ; Linder., Ralph E. ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1966
Stock Number PB-280 888
Additional Subjects Pesticides ; Toxicology ; Insecticides ; Liver ; Cholinesterase inhibitors ; Metabolism ; Rats ; Bioassay ; Laboratory animals ; Experimental data ; Chlorine organic compounds ; Tables(Data) ; Parenteral infusions ; Body weight ; Mortality ; Dosage ; Phosphorus organic compounds ; Carbamates ; Reprints ; DDVP insecticide ; Parathion ; Toxic substances ; Isolan ; Carbamic acid/dimethyl-isopropyl-methyl-pyrazolyl
Library Call Number Additional Info Location Last
NTIS  PB-280 888 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 4p
To test the effect of a single pass through the liver, 'Isolan' was injected directly into the hepatic portal system (intestinal vein) in one group of rats and into the general circulation (femoral vein) in another group. Simlar investigations were conducted with two organic phosphorus compounds-dichlorvos, a direct inhibitor of cholinesterase, and parathion, an indirect inhibitor. It is well known that prathion is converted to the highly toxic paraoxon in the liver, but it is presumably in the liver also that it is eventually detoxified. Even though other techniques will have to be used to explain fully the pattern of toxicity of 'Isolan' when given by different routes, the technique presented in this report is a useful and relatively simple procedure for learning the net effect of the liver on the metabolism of chemicals in intact laboratory animals.