Record Display for the EPA National Library CatalogRECORD NUMBER: 5 OF 10
|Main Title||Light Microscopy and Ultrastructure of Liver of Rats Fed Polychlorinated Biphenyls.|
|Author||Kimbrough, Renate D. ; Linder, Ralph E. ; Gaines., Thomas B. ;|
|CORP Author||Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs.|
|Stock Number||PB-277 597|
|Additional Subjects||Hazardous materials ; Liver ; Toxicology ; Chlorine organic compounds ; Diets ; Rats ; Chlorine organic compounds ; Ingestion(Biology) ; Laboratory animals ; Experimental data ; Dosage ; Bioassay ; Sex ; Toxicity ; Reprints ; Polychlorinated biphenyls ; Toxic substances ; Aroclor 1254 ; Aroclor 1260 ; Biphenyl/hexachloro ; Biphenyl/chloro|
Polychlorinated biphenyls (PCB) are widely distributed in the environment. Two PCB were fed to groups of 10 male and 10 female weanling Sherman strain rats in their diet at levels of 0, 20, 100, and 500 ppm Aroclor 1254 and 0, 20, 100, 500, and 1000 ppm Aroclor 1260 for 8 mo. The livers of all rats exposed to the Aroclors weighed more than those of the controls. This difference was significant for all exposed male rats (p < 0.025) and for the females fed 500 ppm of either compound.