Record Display for the EPA National Library Catalog


Main Title Induction of Adenofibrosis and Hepatomas of the Liver in BALB/cJ Mice by Polychlorinated Biphenyls (Aroclor 1254).
Author Kimbrough, Renate D. ; Linder., Ralph E. ;
CORP Author Environmental Protection Agency, Chamblee, Ga. Chamblee Toxicology Lab.
Year Published 1974
Stock Number PB-280 833
Additional Subjects Pesticides ; Toxicology ; Bioassay ; Mice ; Laboratory animals ; Experimental data ; Ingestion(Biology) ; Male ; Diets ; Liver ; Physiological effects ; Chlorine organic compounds ; Biphenyl/chloro ; Reprints ; Aroclor 1254 ; Hepatomas ; Toxic substances ; Polychlorinated biphenyls ; Adenofibrosis
Library Call Number Additional Info Location Last
NTIS  PB-280 833 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Two groups of 50 BALB/cj inbred male mice were fed 300 ppm of a polychlorinated biphenyl, Aroclor 1254, in the diet for 11 and 6 months, respectively. The 6 months' feeding was followed by 5 months' recovery. Two additional groups of 50 mice each were fed plain chow. All 22 surviving mice fed Aroclor 1254 for 11 months had greatly enlarged livers representing 25% of their body weight, whereas those fed the experimental diet for 6 months only had slightly, but significantly, enlarged livers. Adenofibrosis was observed in all 22 livers of mice fed Aroclor 1254 for 11 months but not in the other groups. Of the 22 mice fed 300 ppm Aroclor 1254 for 11 months, 9 had 10 hepatomas measuring 0.1-1.5 cm in diameter. One of 24 surviving mice fed Aroclor 1254 for only 6 months, followed by a control diet for 5 months, had a hepatoma 0.3 cm in diameter. No controls had hepatomas.