||Collection, Chemical Fractionation, and Mutagenicity Bioassay of Ambient Air Particulate.
Huisingh, Joellen Lewtas ;
Waters, Michael ;
Claxton, Larry ;
Kolber, Alan ;
Wolff, Thomas ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Research Triangle Inst., Research Triangle Park, NC.
Air pollution ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The influence of industrialization and consequent increased concentration of urban particulate matter on the incidence of cancer has long been a concern. The first bioassays used to evaluate complex ambient air samples were whole-animal carcinogenesis bioassays. In these studies, organic extracts of urban particulate matter were found to be carcinogenic in rodents. Carcinogenic polycyclic aromatic hydrocarbons (PAH), such as benzo(a)pyrene, were detected in these extracts; however, these compounds did not account for all of the carcinogenic activity reported.