"As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts. As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced. Protein structures better illustrate structure-function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing open-ended questions highlighting "What We Don't Know," introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text. Thought-provoking end-of-chapter questions have been expanded to all chapters, including questions on developmental biology, tissues and stem cells, the immune system, and pathogens"-- Part I. Introduction to the cell. Cells and genomes ; Cell chemistry and bioenergetics ; Proteins -- Part II. Basic genetic mechanisms. DNA, chromosomes, and genomes ; DNA replication, repair, and recombination ; How cells read the genome : from DNA to protein ; Control of gene expression -- Part III. Ways of working with cells. Analyzing cells, molecules, and systems ; Visualizing cells -- Part IV. Internal organization of the cell. Membrane structure ; Membrane transport of small molecules and the electrical properties of membranes ; Intracellular compartments and protein sorting ; Intracellular membrane traffic ; Energy conversion : mitochondria and chloroplasts ; Cell signaling ; The cytoskeleton ; The cell cycle ; Cell death ; Cell junctions and the extracellular matrix -- Part V. Cells in their social context. Cancer ; Development of multicellular organisms ; Stem cells and tissue renewal ; Pathogens and infection ; The innate and adaptive immune systems -- Glossary.